Pomacel 4mg capsules | Pomalidomide | Millionpharma

POMACEL 4MG

ANTI-NEOPLASTIC

DESCRIPTION

Pomalidomide is sold under the brand name Pomacel 4mg and it belongs to anti-neoplastic drugs

Pomacel 4mg is doable as orally bioavailable thalidomide derivative associated with numerous therapeutic activities such as: immune modulatory, anti-angiogenesis, anti-neoplastic.

Pomacel 4mg combination with dexamethasone will cause liver injury

CLINICAL USE

The primary indication of Pomacel 4mg is used in the treatment of Multiple Myeloma condition.

In this condition, Pomacel 4mg is used by combining with dexamethasone.

Pomacel 4mg capsules are applicable in;

Previously the Patients treated with two treatment such as proteasome inhibitor & Lenalidomide.

Patients who are suffered with disease progression condition

Pomacel 4mg treatment should be followed within 60 days in patients who are concluded the last treatment.

MECHANISM OF ACTION

Pomacel 4mg capsules has three primary pharmacological activities against cancer cells.

Pomalidomide includes in the way cancer proliferation and provoke the apoptosis of cancer cells.

Pomalidomide enhance the T cell & natural killer cells interceding immunity & inhibits the formation of pro inflammatory cytokines from monocytes.

Pomalidomide forbid the new cell formation. The binding of Pomalidomide to active site of targeted cell causes inhibition of ubiquitin ligase action.

Brand : Pomacel 

Ingredients : Pomalidomide 

Strength : 4mg

Manufactured : Glenmark Pharma 

Package : 21 capsules

PHARMACOKINETICS

The time to high serum concentration of Pomalidomide is reaches between 2 to 3 hours.

It should be administered with or without food. Hence No effect of food should be produced;

Volume of distribution of Pomalidomide is between 62 & 138L in steady state.

The Pomalidomide distribution by 67% of serum level at after 4 hours of drug intake.

human plasma protein by bounding range of 12% & 44%.

Hepatically mediated through CYP1A2, CYP3A4 is Pomalidomide is metabolized.

Pomalidomide clearance value is 7 to 10L/hr.

Doses are excreted via urine 73% & feces 15% respectively.

Doses are excreted as an unchanged form via urine 2% & feces 8%.

Pomalidomide half-life period is 9.5 hours.

DOSAGE MANAGEMENT

During multiple myeloma malignancies;

The dosage recommendation of Pomacel 4mg capsules is 4mg should be administered as a single dose for 1 to 21 days of successive 28-day cycles.

Pomacel is combined with dexamethasone with low dose.

Administrate Dexamethasone on day 1, 8, 15 & 22 of each 28-day cycle.

The prescribed dose of dexamethasone is 40mg should be administered the patient having weight about ≤ 75kg.

The prescribed dose of dexamethasone is 20mg given for patient’s weight Greater than 75kg

Dosage alteration during hematological toxicities;

Neutropenia;

ANC <500/mcL: Pomacel treatment should be postponed and check the CBC weekly.

ANC ≥ 500/mcL: Pomacel therapy should be continued by 3mg/day

For each successive drop <500/mcL: Pomacel 4mg should be postponed.

ANC ≥ 500/mcL: Continue the Pomacel therapy with 1mg/day.

Thrombocytopenia:

Platelets count <25000/mcL: Pomacel therapy should be postponed and check CBC

Platelets count ≥50000/mcL: 3mg of Pomacel should be taken daily

With strong CYP1A2:

Pomacel combined with CYP1A2 substrates causes increasing the plasma concentration of Pomalidomide and leads to elevate the risk of Pomalidomide.

In renal damaged patients;

In severe renal impaired patients, the suggested dose of Pomacel is 3mg per day.

In hepatic impaired patients;

The advised dose is 3mg/day & in severe condition, the suggested dose is 2mg/day given for mild to moderate patients.

The most probable worsening condition of Pomacel 4mg is;

Venous & arterial thromboembolism

Embryo fetal damage.

FOR MORE INFO

CONTACT NO : +91-9940472902

EMAIL : millionhealthpharmaceuticals@gmail.com

WEBSITE URL : https://millionpharma.com/pomacel-4mg.php