Abevmy 400mg (mylan) | Bevacizumab | MHP
ABEVMY 400MG/16ML
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NON-SQUAMOUS |
DESCRIPTION
Bevacizumab is a drug sold under the name of Abevmy 400mg and which is categorized as monoclonal anti-body & anti-angiogenesis When Abevmy 400mg concomitant use with human monoclonal antibody IgG1, that circumstance and prohibits the biological action of human vascular endothelial growth factor (VEGF).
USAGE
Abevmy 100mg is indicated for the treatment of some of the conditions like :
Metastatic colon or rectal cancer
Non-squamous, non-small cell lung cancer
Glioblastoma
Metastatic renal cell cancer
Metastatic cervical cancer
Epithelial ovarian, fallopian tube or peritoneal cancer.
MECHANISM OF ACTION
Abevmy 400mg Injection comprises an active compound like Bevacizumab which binds to VEGF and avoid the communication of VEGF to its receptors like Flt-1 & KDR) present on the surface of the cells
This interaction prevents endothelial cell multiplication and new blood vessel production occurs
Hence in counts cessation of metastatic cancer cells development happens
Ingredients : Bevacizumab
Strength : 400mg/16ml
Manufactured : Mylan Pharmaceuticals
Package : 4ml in a 1 vial
DISTRIBUTION
The volume of distribution is 2.9 (22%) LELIMINATION
The Bevacizumab half-life period is 20days (11 to 50days)DOSAGE MANAGEMENT
Key point:
Avoid administration of Abevmy 400mg Injection before at least 28 days following surgery and the wound is completely cured
colorectal carcinoma:
Concomitant use with 5-fluorouracil based chemotherapy is the usual dosage of Abevmy: While concomitant use with bolus IFL the dose is 5mg/kg of Abevmy for every 2 weeks IV.
While in combination with FOLFOX4 the dose is 10mg/kg of Abevmy for every 2 weeks IV
5mg/kg IV Abevmy for every 2 weeks or 7.5 mg/kg Abevmy as IV every 3 weeks by concurrently used with fluoropyrimidine Irinotecan or fluoropyrimidine oxaliplatin based therapy
Non-small cell lung cancer:
While combining with carboplatin and paclitaxel: The Abevmy usual dosage is 15mg/kg IV for every 3 weeks by
Glioblastoma:
For every 2 weeks: 10mg/kg of Abevmy 400mg Injection administered IV
Metastatic renal cell cancer:
Concurrent use with interferon alfa: The Abevmy usual dosage is 10mg/kg IV for every 2 weeks
Metastatic cervical cancer:
Combining with paclitaxel and cisplatin or with paclitaxel and topotecan: The drug Abevmy usual dosage is 15mg/kg of Abevmy given intravenously for every 3 weeks
Epithelial ovarian, fallopian tube or peritoneal cancer:
Platinum opposing:
Concurrent use with paclitaxel, pegylated liposomal doxorubicin or topotecan: The Abevmy regular dosage is 10mg/kg of Abevmy for every 2 weeks
Or Combining with topotecan: The Abevmy regular dosage 15mg/kg of Abevmy given through IV for every 3 weeks
Platinum responsive:
concomitant with carboplatin and paclitaxel for 6 to 8 cycles: The drug Abevmy recommended dosage of is 15mg/kg given IV for 3 weeks
Combining with gemcitabine & carboplatin for 6 to 10 cycles: The Abevmy recommended dosage is 15mg/kg of Abevmy given IV for 3 weeks
Preparation & administration:
Abevmy is intravenous solution
At initial infusion:
given IV infusion over 90 minutes
Following infusions:
give second infusion over 60 minutes, if tolerated
Administer all following infusion over 30minutes
Abevmy IV infusion is prepared in aseptic condition
Abevmy 400mg containing 16ml solution whereas 100mg containing 4ml
Abevmy dilute into 100ml of 0.9% NS
Do not dilute with dextrose solution
Dispose the remaining portion of medicine which is left in a vial.
FOR MORE INFO
CONTACT NO : +91-9940472902EMAIL : millionhealthpharmaceuticals@gmail.com
WEBSITE URL : https://millionpharma.com/abevmy-400mg.php
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