Bevarest (Bevacizumab) 100mg & 400mg Injection-uses,dose,side effects,price india


BEVAREST

Bevarest 400mg injection

CERVICAL CANCER

DESCRIPTION

Bevacizumab is a drug sold under the name of Bevarest 400mg and which is categorized as monoclonal anti-body & anti-angiogenesis 

When Bevarest 400mg Injection concomitant use with human monoclonal antibody IgG1, that circumstance and prohibits the biological action of human vascular endothelial growth factor (VEGF)


Bevarest is indicated for the treatment of some of the conditions like Metastatic colon or rectal cancer Non-squamous, non-small cell lung cancer Glioblastoma Metastatic renal cell cancer Metastatic cervical cancer Epithelial ovarian, fallopian tube or peritoneal cancer

MECHANISM OF ACTION

Bevarest 400mg comprises an active compound like Bevacizumab which binds to VEGF and avoid the communication of VEGF to its receptors like Flt-1 & KDR) present on the surface of the cells This interaction prevents endothelial cell multiplication and new blood vessel production occurs Hence in counts cessation of metastatic cancer cells development happens


Bevarest 400mg Injection

BEVAREST 400mg


Brand : Bevarest
Ingredients : Bevacizumab 
Strength : 400mg/16ml & 100mg/4ml 
Manufactured : Emcure Pharmaceuticals 
Package : 400mg of Bevacizumab containing vial

Distribution:

The volume of distribution is 2.9 (22%) L 
Elimination 
The Bevacizumab half life period is 20days (11 to 50days)

KEY POINT

Avoid administration of Bevarest 400mg Injection before at least 28 days following surgery and the wound is completely curedMETASTATIC COLORECTAL CARCINOMA

Concomitant use with 5-fluorouracil based chemotherapy is the usual dosage of Bevarest : While concomitant use with bolus IFL the dose is 5mg/kg of Bevarest for every 2 weeks IV. While in combination with FOLFOX4 the dose is 10mg/kg ofBevarest for every 2 weeks IV 5mg/kg IV Bevarestfor every 2 weeks or 7.5 mg/kg Bevarest as IV every 3 weeks by concurrently used with fluoropyrimidine Irinotecan or fluoropyrimidine oxaliplatin based therapyNON-SMALL CELL LUNG CANCER

While combining with carboplatin and paclitaxel : The Bevarest usual dosage is 15mg/kg IV for every 3 weeks byGLIOBLASTOMA

For every 2 weeks : 10mg/kg of Bevarestadministered IVMETASTATIC CERVICAL CANCER

Combining with paclitaxel and cisplatin or with paclitaxel and topotecan : The drug Bevarest usual dosage is 15mg/kg of Bevarest given intravenously for every 3 weeks
METASTATIC RENAL CELL CANCER

Concurrent use with interferon alfa : The Bevarestusual dosage is 10mg/kg IV for every 2 weeksEPITHELIAL OVARIAN, FALLOPIAN TUBE OR PERITONEAL CANCER

Platinum opposing: Concurrent use with paclitaxel, pegylated liposomal doxorubicin or topotecan :The Bevarest regular dosage is 10mg/kg of Bevarest for every 2 weeks Or Combining with topotecan : The Bevarest regular dosage 15mg/kg of Bevarest given through IV for every 3 weeks Platinum responsive concomitant with carboplatin and paclitaxel for 6 to 8 cycles : The drug Bevarestrecommended dosage of is 15mg/kg given IV for 3 weeks Combining with gemcitabine & carboplatin for 6 to 10 cycles : The Bevarest recommended dosage is 15mg/kg of Bevarest given IV for 3 weeksPREPARATION & ADMINISTRATION

Bevarest 400mg Injection is intravenous solution At initial infusion: given IV infusion over 90 minutes Following infusions: give second infusion over 60 minutes, if tolerated Administer all following infusion over 30minutes Bevarest IV infusion is prepared in aseptic condition Bevarest 400mg containing 16ml solution whereas 100mg containing 4ml Bevarestdilute into 100ml of 0.9% NS Do not dilute with dextrose solution Dispose the remaining portion of medicine which is left in a vial

FOR FURTHER INFO

MOBILE NO : +91-9940472902

EMAIL : millionhealthpharmaceuticals@gmail.com

WEBSITE URL : https://millionpharma.com/bevarest.php

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