Bevacirel 400mg | Bevacizumab | MHP


BEVACIREL 400MG



bevacirel 400mg Injection
BEVACIREL 400MG

DESCRIPTION

Bevacizumab is a drug sold under the name of Bevacirel 400mg and which is categorized as monoclonal anti-body & anti-angiogenesis When Bevacirel concomitant use with human monoclonal antibody IgG1, that circumstance and prohibits the biological action of human vascular endothelial growth factor (VEGF).

USAGE

Bevacirel 400mg Injection is indicated for the treatment of some of the conditions like :
Metastatic colon or rectal cancer 
Non-squamous, non-small cell lung cancer 
Glioblastoma 
Metastatic renal cell cancer 
Metastatic cervical cancer
Epithelial ovarian, fallopian tube or peritoneal cancer

MECHANISM OF ACTION

Bevacirel 400mg Injection comprises an active compound like Bevacizumab which binds to VEGF and avoid the communication of VEGF to its receptors like Flt-1 & KDR) present on the surface of the cells
This interaction prevents endothelial cell multiplication and new blood vessel production occurs
Hence in counts cessation of metastatic cancer cells development happens

Brand : Bevacirel
Ingredients : Bevacizumab
Strength : 400mg/16ml
Manufactured : Reliance Life Sciences
Package : 16ml in a 1 vial

PHARMACOKINETICS

DISTRIBUTION

The volume of distribution is 2.9 (22%) L

ELIMINATION

The Bevacizumab half-life period is 20days (11 to 50days)

Key point: 
Avoid administration of Bevacirel before at least 28 days following surgery and the wound is completely cured 
colorectal carcinoma: 
Concomitant use with 5-fluorouracil based chemotherapy is the usual dosage of Bevacirel: While concomitant use with bolus IFL the dose is 5mg/kg of Bevacirel for every 2 weeks IV. 
While in combination with FOLFOX4 the dose is 10mg/kg of Bevacirel for every 2 weeks IV 
5mg/kg IV Bevacirel for every 2 weeks or 7.5 mg/kg Bevacirel as IV every 3 weeks by concurrently used with fluoropyrimidine Irinotecan or fluoropyrimidine oxaliplatin based therapy 
Non-small cell lung cancer:
While combining with carboplatin and paclitaxel: The Bevacirel usual dosage is 15mg/kg IV for every 3 weeks by
Glioblastoma: 
For every 2 weeks: 10mg/kg of Bevacirel administered IV 
Metastatic renal cell cancer: 
Concurrent use with interferon alfa: The Bevacirelusual dosage is 10mg/kg IV for every 2 weeks 
Metastatic cervical cancer: 
Combining with paclitaxel and cisplatin or with paclitaxel and topotecan: The drug Bevacirel usual dosage is 15mg/kg of Bevacirel given intravenously for every 3 weeks 
Epithelial ovarian, fallopian tube or peritoneal cancer:
Platinum opposing:
Concurrent use with paclitaxel, pegylated liposomal doxorubicin or topotecan: TheBevacirel regular dosage is 10mg/kg of Bevacirel for every 2 weeks 
Or Combining with topotecan: The Bevacirel regular dosage 15mg/kg of Bevacirel given through IV for every 3 weeks
Platinum responsive:
concomitant with carboplatin and paclitaxel for 6 to 8 cycles: The drug Bevacirel recommended dosage of is 15mg/kg given IV for 3 weeks 
Combining with gemcitabine & carboplatin for 6 to 10 cycles: The Bevacirel recommended dosage is 15mg/kg of Bevacirel given IV for 3 weeks 
Preparation & administration:
Bevacirel is intravenous solution
At initial infusion:
given IV infusion over 90 minutes
Following infusions:
give second infusion over 60 minutes, if tolerated
Administer all following infusion over 30minutes
Bevacirel IV infusion is prepared in aseptic condition
Bevacirel 400mg containing 16ml solution whereas 100mg containing 4ml
Bevacirel dilute into 100ml of 0.9% NS
Do not dilute with dextrose solution
Dispose the remaining portion of medicine which is left in a vial.

CONTACT US :

MOBILE NO : +91-9940472902

EMAIL : millionhealthpharmaceuticals@gmail.com

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