Avastin 100mg - Anticancer drugs | view uses, side effects and price | MHP

AVASTIN

AVASTIN 100MG

DESCRIPTION

  Bevacizumab is a drug sold under the name of Avastin 100mg and which is categorized as monoclonal anti-body & anti-angiogenesis

When Avastin concomitant use with human monoclonal antibody IgG1, that circumstance and prohibits the biological action of human vascular endothelial growth factor (VEGF)

Usage

Avastin is indicated for the treatment of some of the conditions like Metastatic colon or rectal cancer Non-squamous, non-small cell lung cancer Glioblastoma Metastatic renal cell cancer Metastatic cervical cancer Epithelial ovarian, fallopian tube or peritoneal cancer

Mechanism of Action

  Avastin 100mg comprises an active compound like Bevacizumab which binds to VEGF and avoid the communication of VEGF to its receptors like Flt-1 & KDR) present on the surface of the cells This interaction prevents endothelial cell multiplication and new blood vessel production occurs Hence in counts cessation of metastatic cancer cells development happens

Brand : Avastin
Ingredients : Bevacizumab
Strength : 400mg/16ml & 100mg/4ml
Manufactured : Roche
Package : 400mg of Bevacizumab containing vial
ADME PROPERTIES
Distribution:
The volume of distribution is 2.9 (22%) L
Elimination
The Bevacizumab half life period is 20days (11 to 50days)
KEY POINT

 Avoid administration of Avastin 100mg Injection  before at least 28 days following surgery and the wound is completely curedMETASTATIC COLORECTAL CARCINOMA

 Concomitant use with 5-fluorouracil based chemotherapy is the usual dosage of Avastin : While concomitant use with bolus IFL the dose is 5mg/kg of Avastin for every 2 weeks IV. While in combination with FOLFOX4 the dose is 10mg/kg ofAvastin for every 2 weeks IV 5mg/kg IV Avastin for every 2 weeks or 7.5 mg/kg Avastin as IV every 3 weeks by concurrently used with fluoropyrimidine Irinotecan or fluoropyrimidine oxaliplatin based therapyNON-SMALL CELL LUNG CANCER

 While combining with carboplatin and paclitaxel : The Avastin 100mg Injection usual dosage is 15mg/kg IV for every 3 weeks byGLIOBLASTOMA

 For every 2 weeks : 10mg/kg of Avastinadministered IVMETASTATIC CERVICAL CANCER

 Combining with paclitaxel and cisplatin or with paclitaxel and topotecan : The drug Avastin usual dosage is 15mg/kg of Avastin 100mg given intravenously for every 3 weeks

METASTATIC RENAL CELL CANCER

 Concurrent use with interferon alfa : The Avastinusual dosage is 10mg/kg IV for every 2 weeks

EPITHELIAL OVARIAN, FALLOPIAN TUBE OR PERITONEAL CANCER

  Platinum opposing: Concurrent use with paclitaxel, pegylated liposomal doxorubicin or topotecan :The Avastin regular dosage is 10mg/kg of Avastin 100mg Injection for every 2 weeks Or Combining with topotecan : The Avastin regular dosage 15mg/kg ofAvastin given through IV for every 3 weeks Platinum responsive concomitant with carboplatin and paclitaxel for 6 to 8 cycles : The drug Avastinrecommended dosage of is 15mg/kg given IV for 3 weeks Combining with gemcitabine & carboplatin for 6 to 10 cycles : The Avastin recommended dosage is 15mg/kg of Avastin given IV for 3 weeks

PREPARATION & ADMINISTRATION

  Avastin is intravenous solution At initial infusion: given IV infusion over 90 minutes Following infusions: give second infusion over 60 minutes, if tolerated Administer all following infusion over 30minutes Avastin IV infusion is prepared in aseptic condition Avastin 400mg containing 16ml solution whereas 100mg containing 4ml Avastindilute into 100ml of 0.9% NS Do not dilute with dextrose solution Dispose the remaining portion of medicine which is left in a vial

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